Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 16, Pages 7677-7681Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo5012009
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Funding
- National Natural Science Foundation of China [21102071]
- Fundamental Research Funds for the Central Universities [1107020522, 1082020502]
- Jiangsu 333 Program
- Changzhou Jin-Feng-Huang Program
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We have demonstrated that 3,3,3-trifluoroacetaldimine (S)-1 easily reacts with indole derivatives under Friedel Crafts reactions to provide reliable and generalized access to biologically interesting compounds containing the CF3CH(NH2)- pharmacophoric group. The reactions proceed with high rates and generally excellent yields (>90%) and stereochemical outcomes (99:1 dr).
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