Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 8, Pages 3774-3782Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo400261v
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Funding
- National Natural Science Foundation of China [20932002, 21172076]
- National Basic Research Program of China (973 Program) [2011CB808600]
- Guangdong Natural Science Foundation [10351064101000000, S2012040007088]
- China Postdoctoral Science Foundation [2012T50673]
- Fundamental Research Funds for the Central Universities [2012ZP0003, 2012ZB0011]
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An efficient copper-catalyzed C-N bond cleavage of aromatic methylamines was developed to construct pyridine derivatives. With neat conditions and facile operation, the fragment-assembling strategy. affords a broad. range Of 2,4,6-trisubstituted pyridines in up to 95% yield from simple and readily available starting materials. Interestingly, when pyridin-2-yl methylamine Was employed as the substrate, alpha-alkylation reaction of ketones readily occurred to give beta-(pyridin-2-yl) ketones instead of the 2,4,6-trisubstituted pyridines.
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