Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 13, Pages 6763-6768Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo400774u
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- ETH Zurich
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Simplified syntheses suited for large scale preparations of the two hypervalent iodine reagents 1 and 2 for electrophilic trifluoromethylation are reported. In both cases, the stoichiometric oxidants sodium metaperiodate and tertbutyl hypochlorite have been replaced by trichloroisocyanuric acid. Reagent 1 is accessible in a one pot procedure from 2-iodobenzoic acid in 72% yield. Reagent 2 was prepared via fluoroiodane 11 in a considerably shorter reaction time and with no need of an accurate temperature control.
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