4.7 Article

Synthesis of 3-Cyanoindole Derivatives Mediated by Copper(I) Iodide Using Benzyl Cyanide

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 7, Pages 3374-3378

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo3028278

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Funding

  1. Research Grants Council of Hong Kong (GRF) [PolyU5010/11P]
  2. PolyU Development Grant [1BD07]
  3. State Key Laboratory of Chirosciences [BBX-3]

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Copper-mediated direct and regioselective C3-cyanation of indoles using benzyl cyanide as the cyanide anion source is presented. A wide range of indoles undergo cyanation smoothly by employing a reaction system of copper(I) iodide under open-to-air vessels.

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