Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 3, Pages 831-845Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo402414k
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Funding
- EPSRC
- ERC
- European Commission
- University of Edinburgh
- Erasumus student exchange program
- Scottish Funding Council
- Shasun Pharma Solutions
- Engineering and Physical Sciences Research Council [EP/I004769/1, EP/I004769/2] Funding Source: researchfish
- EPSRC [EP/I004769/1, EP/I004769/2] Funding Source: UKRI
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Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chiral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepare chiral azaarene-containing compounds: exploitation of the C=N bond embedded within certain azaarenes to activate adjacent functionality in catalytic asymmetric reactions. Work in this area has resulted in the development of several different types of catalytic enantio-selective processes, including reductions, nucleophilic additions, and reductive couplings. It is hoped that this Perspective will encourage more researchers to work in this promising area.
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