Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 2, Pages 717-722Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo302071s
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Funding
- NIH [RO1GM087605]
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Nitroarylacetates are useful small molecular building blocks that act as precursors to alpha-ketoesters and aryl nitromethanes as well as alpha-amino acids. Methods were developed that produce each of these compound types in good yields. Two different conditions for decarboxylation are discussed for substrates with neutral and electron-poor aryl groups versus electron-rich aryl groups. For formation of the alpha-ketoesters, new mild conditions for the Nef disproportionation were identified.
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