4.7 Article

Cyclization Reactions of Anode-Generated Amidyl Radicals

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 1, Pages 379-391

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo402623r

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Funding

  1. National Science Foundation [CHE 1151121]
  2. Direct For Mathematical & Physical Scien
  3. Division Of Chemistry [1151121] Funding Source: National Science Foundation

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Amidyl radicals have been generated from amides under mild conditions electro-oxidatively. Their reactivity toward electron-rich double bonds to form five- and six-membered rings has been demonstrated experimentally and explored with density functional theory (DFT) calculations (UB3LYP/6-31G(d,p)).

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