Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 7, Pages 3300-3305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo400202w
Keywords
-
Categories
Funding
- Loker Hydrocarbon Research Institute
- NSF [DBI-0821671, CHE-0840366]
- NIH [S10 RR25432]
- University of Southern California Center for High-Performance Computing and Communications
Ask authors/readers for more resources
A feasible nucleophilic trifluoromethylating protocol has been developed using trifluoroacetaldehyde hydrate as an atom-economical trifluoromethyl source. The reaction was found to be applicable to the nucleophilic trifluoromethylation of a broad spectrum of carbonyl compounds with satisfactory yields in general. DFT calculations have been performed to provide mechanistic insight into methoxyethanol and hexafluoroacetone hydrate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available