Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 6, Pages 2617-2625Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo302815m
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- UGC
- IIT Kanpur, India
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An efficient and practical strategy for the synthesis of highly functionalized racemic and non-racemic 4,5-dihydropyrroles via domino ring-opening cyclization (DROC) of activated aziridines with malononitrile in excellent yield and stereoselectivity is described. The reaction serves as a tool for the synthesis of a large variety of substituted 4,5-dihydropyrroles in enantiomerically pure forms.
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