Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 18, Pages 9424-9430Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo401652k
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Funding
- National Natural Science Foundation of China [21176223]
- National Natural Science Foundation of Zhejiang Province [LY13B020016]
- Key Innovation Team of Science and Technology in Zhejiang Province [2010R50018]
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An I-2-induced 1,3-dipolar cycloaddition reaction has been developed for the synthesis of benzo[f]-isoindole-1,3-dicarboxylates from quinones and N-substituted amino esters. The reaction proceeds in good to excellent yields in one step from 3 equiv of amino ester to react with the quinone structure. The utility of this transformation has been highlighted by its use for the construction of benzo[f]-isoindole-1,3-dicarboxylates, which have been identified in natural products exhibiting important biological activities.
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