Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 24, Pages 12288-12313Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo4020722
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Funding
- DST, CSIR
- UGC, New Delhi
- CSIR, New Delhi
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Here we describe several useful strategies to a variety of unusual a-amino acid derivatives and peptides based on building block approach. These building blocks are suitable for modification at an amino acid as well as at a peptide level. Moreover, these methods have embedded several points for diversification and are capable of producing a library of modified amino acids and peptides. We have employed highly atom-economic processes such as the Diels-Alder reaction, [2 + 2 + 2] cycloaddition, Suzuki-Miyaura cross-coupling, and olefin metathesis as key steps to assemble various unnatural amino acid derivatives and peptides. In some instances, we have used rongalite to generate Diels-Alder precursors.
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