Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 12, Pages 5964-5969Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo400651k
Keywords
-
Categories
Funding
- Russian Foundation for Basic Research [11-04-00131-a]
Ask authors/readers for more resources
New oligonucleotide analogues with triazole internucleotide linkages were synthesized, and their hybridization properties were studied. The analogues demonstrated DNA binding affinities similar to those of unmodified oligonucleotides. The modification was shown to protect the oligonucleotides from nuclease hydrolysis. The modified oligonucleotides were tested as PCR primers. Modifications remote from the 3'-terminus were tolerated by polymerases. Our results suggest that these new oligonucleotide analogues are among the most promising triazole DNA mimics characterized to date.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available