4.7 Article

Synthesis of Sulfonated Oxindoles by Potassium Iodide Catalyzed Arylsulfonylation of Activated Alkenes with Sulfonylhydrazides in Water

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 14, Pages 7343-7348

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo401069d

Keywords

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Funding

  1. National Natural Science Foundation of China [21102130]
  2. Key Innovation Team of Science & Technology in Zhejiang Province [2010R50018, 2O11R50017]

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A catalytic system consisting of KI, 18-crown-6, and TBHP for arylsulfonylation of activated alkenes with sulfonylhydrazides as sulfonyl precursor is described. This protocol provides a practical and environmentally benign method for the construction of sulfonated oxindoles in water.

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