Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 7, Pages 3429-3433Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo400115r
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Funding
- Novartis International AG (Basel, Switzerland)
- Nippon Chemical
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By utilizing Rh catalysts ligated by the P-chirogenic ligands QuinoxP* and DuanPhos, 3,3,3-trifluoroprop-1-en-2-yl acetate could be hydroformylated and subsequently oxidized to yield enantiomerically pure 2-trifluoromethyllactic acid.
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