4.7 Article

Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 8, Pages 4190-4195

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo400390t

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Funding

  1. Danish Agency for Science, Technology and Innovation

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A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

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