Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 18, Pages 9494-9498Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo4014904
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Funding
- National Natural Science Foundation of China [21172106, 21074054]
- National Basic Research Program of China [2010CB923303]
- Research Fund for the Doctoral Program of Higher Education of China [20120091110010]
- Natural Science Foundation of China [21272178]
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A copper-mediated C2-cyanation of indoles using cheap and commercially available acetonitrile as the nonmetallic cyanide source was achieved through sequential C-C and C-H bond cleavages. The installation of a removable pyrimidyl group on the indole nitrogen atom is the key for this C2 selectivity. This approach provides a novel and alternative route leading to indole-2-carbonitrile.
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