Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 1, Pages 413-418Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo402385g
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Funding
- Normandie Universite
- CNRS
- CRUNCH
- LABEX SYNORG [ANR-11-LABX-0029]
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alpha- and beta-substituted N,N-diethylacrylamides undergo copper-mediated direct beta-trifluoromethylation. The amide moiety acts as a directing group for the regio- and the stereo-controlled introduction of the trifluoromethyl group. The reaction is carried out under acidic conditions in the presence of Umemoto's reagent. This method does not require prefunctionalized substrates and delivers excellent stereoselectivity.
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