Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 21, Pages 10853-10859Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo4018414
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Funding
- MEXT (Japan) program Strategic Molecular and Materials Chemistry through Innovative Coupling Reactions of Hokkaido University
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Direct alpha-allylation of alpha-branched aldehydes was successfully carried out with a readily available allyl ester by combined use of two catalytic systems: Tsuji-Trost allylation reaction with an achiral palladium complex and enamine catalysis with a chiral primary alpha-amino acid. A quaternary carbon stereogenic center was constructed stereoselectively to give various 2,2-disubstituted pent-4-enals in good yields with high enantioselectivity.
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