Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 18, Pages 9457-9463Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo401109w
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- ChemBiotech (Munster, Germany)
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6-Substituted pyrrolo-dC-pyrrolo-dC mismatches selectively capture silver ions to form extraordinarily stable metal-mediated base pairs. One single modification in a 12-mer duplex causes a T-m increase of 36.0 degrees C relative to the metal-free mismatched duplex. Spectrophotometric titrations as well as ESI mass spectra confirmed the binding of two silver ions per base pair. The Ag+-mediated base pairs may permit the construction of metal-responsive DNA with a very high silver loading.
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