Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 17, Pages 7640-7645Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo301001j
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Funding
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR, Rome, Italy) [2008A7P7YJ]
- European Commission
- FSE (Fondo Sociale Europeo)
- Calabria Region
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A novel approach to 3-iodothiophenes by direct iodocyclization of alkynylthiol derivatives is presented. A variety of 1-mercapto-3-yn-2-ols 5 (readily available from alkynylation of the corresponding alpha-mercapto ketones or alpha-mercapto esters) were smoothly converted into the corresponding 3-iodothiophene derivatives 6 in good yields by reaction with molecular iodine in the presence of NaHCO3 at room temperature in MeCN as the solvent.
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