4.7 Article

Synthesis of Isocoumarin Derivatives via the Copper-Catalyzed Tandem Sequential Cyclization of 2-Halo-N-phenyl Benzamides and Acyclic 1,3-Diketones

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 11, Pages 5022-5029

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo300501j

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Funding

  1. National Science Council of the Republic of China [NSC 100-2113-M-003-008-MY3]
  2. National Taiwan Normal University [99T3030-2, 99-D, 100-D-06]

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A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C-C/C-O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-N-phenyl benzamides and acyclic diketones as starting materials were investigated.

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