4.7 Article

Iodine(III)-Mediated Tandem Oxidative Cyclization for Construction of 2-Nitrobenzo[b]furans

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 17, Pages 7711-7717

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo301162x

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Funding

  1. National Natural Science Foundation of China [81161120402]
  2. National 863 Program of China [2012AA020303]

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Various 3-alkyl-2-nitrobenzo[b]furans were synthesized from common intermediate 2-(2-nitroethyl)phenols via a hypervalent iodine-induced oxidative cyclization, with good to excellent yields. This facile route is able to efficiently functionalize 2-nitrobenzo[b]furans, which are difficult to obtain by classical methods.

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