Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 23, Pages 10962-10966Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo302109g
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Funding
- Waseda University [2008A-059]
- Ministry of Education, Science, Sports, and Technology (MEXT), Japan
- National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine [2010-3017]
- Grants-in-Aid for Scientific Research [22655008] Funding Source: KAKEN
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A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC50 values of 0.088 and 0.25 mu M, respectively.
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