Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 19, Pages 8723-8732Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo301699z
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Funding
- Portuguese Fundacao para a Ciencia e a Tecnologia (FCT), FEDER [PTDC/QUI-QUI/111879/2009, PTDC/QUI-QUI/118078/2010, FCOMP-01-0124-FEDER-021O82]
- QREN-COMPETE-UE
- FCT [SFRH/BD/28844/2006]
- [IF/00464/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/28844/2006, PTDC/QUI-QUI/118078/2010, PTDC/QUI-QUI/111879/2009] Funding Source: FCT
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The photochemistry of matrix-isolated isoxazole, induced by narrowband tunable UV-light, was investigated by infrared spectroscopy, with the aid of MP2/6-311+ +G(d,p) calculations. The isoxazole photoreaction starts to occur upon irradiation at lambda = 240 nm, with the dominant pathway involving decomposition to ketene and hydrogen cyanide. However, upon irradiation at lambda = 221 nm, in addition to this decomposition, isoxazole was also found to isomerize into several products: 2-formyl-2H-azirine, 3-formylketenimine, 3-hydroxypropenenitrile, imidloylketene, and 3-oxopropanenitrile. The structural and spectroscopic assignment of the different photoisomerization products was achieved by additional irradiation of the lambda = 221 nm photolyzed matrix, using UV-light with lambda >= 240 nm: (i) irradiation in the 330 <= lambda <= 340 nm range induced direct transformation of 2-formyl-2H-azirine into 3-formylketenimine; (ii) irradiation with 310 <= lambda <= 318 nm light induced the hitherto unobserved transformation of 3-formylketenimine into 3-hydroxypropenenitrile and imidoylketene; (iii) irradiation with lambda = 280 nm light permits direct identification of 3-oxopropanenitrile; (iv) under lambda = 240 nm irradiation, tautomerization of 3-hydroxypropenenitrile to 3-oxopropanenitrile is observed. On the basis of these findings, a detailed mechanistic proposal for isoxazole photochemistry is presented.
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