Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 5, Pages 2331-2336Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo2026433
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Funding
- National Natural Science Foundation of China [20972085, 21032004]
- National Basic Research Program of China [2012CB933402]
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An efficient strategy for the synthesis of a variety of 3-substituted isocoumarins has been developed. The reaction proceeded from o-halobenzoic acids and 1,3-diketones via a copper(I)-catalyzed domino reaction in DMF under the action of K3PO4 at 90-120 degrees C without a ligand to afford the corresponding 3-substituted isocoumarin derivatives in good to excellent yields. o-Halobenzoic acids could be o-iodobenzoic acid, o-bromobenzoic acid, and o-chlorobenzoic acid derivatives. 1,3-Diketones could be alkyl- and aryl-substituted 1,3-diketones.
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