Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 14, Pages 6208-6214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo301006e
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [20972070, 21121002]
- National Basic research Program of China (973 Program) [2010CB833300]
- Program for New Century Excellent Talents in University [NCET-11-0265]
- Key laboratory of Elemento-Organic Chemistry
Ask authors/readers for more resources
A primary amin Et-thiourea organocatalyzed intramolecular Michael addition access was developed for the synthesis of trans-dihydrobenzofurans. Under the catalysis of an (R,R)-1,2-diphenylethylamine derived primary amine-thiourea bearing a glucosyl scaffold, the corresponding trans-dihydrobenzofurans were obtained in high yields with excellent level of enantioselectivities (94 to >99% ee). Moreover, an in situ isomerization occurring at high temperature gave good to excellent trans/cis ratios as well (trans/cis: 84/16-96/4).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available