4.7 Article

Preparation of N-Alkyl 2-Pyridones via a Lithium Iodide Promoted O- to N-Alkyl Migration: Scope and Mechanism

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 18, Pages 8220-8230

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo3015424

Keywords

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Funding

  1. National Science Foundation [CHE-0911264]
  2. Research Corporation for Science Advancement, Arnold
  3. Mabel Beckman Foundation Scholars Program, Donors of the American Chemical Society Petroleum Research Fund
  4. Calvin College
  5. Pomona College
  6. Major Research Instrumentation grant of the National Science Foundation [CHE-0922973]
  7. Division Of Chemistry
  8. Direct For Mathematical & Physical Scien [0922973, 0911264] Funding Source: National Science Foundation

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An efficient and inexpensive LiI-promoted O- to N-alkyl migration of 2-benzyloxy-, 2-allyloxy-, and 2-propargyloxypyridines and heterocycles is reported. The reaction produces the corresponding N-alkyl 2-pyridones and analogues under green, solvent-free conditions in good to excellent yields (30 examples, 20-97% yield). This method has been shown to be intermolecular and requires heat and lithium cation to occur.

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