Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 2, Pages 320-327Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo302127d
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [23780113] Funding Source: KAKEN
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A soluble tag-assisted liquid-phase peptide synthesis was successfully established based on simple hydrophobic benzyl alcohols, which can be easily prepared from naturally abundant materials. Excellent precipitation yields can be obtained at each step, combining the best properties of solid-phase and liquid-phase techniques. This approach can also be applied efficiently to fragment couplings, allowing chemical synthesis of several bioactive peptides.
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