4.7 Article

Total Synthesis of Laetevirenol A

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 19, Pages 8762-8767

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo301345a

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Funding

  1. KRICT
  2. Ministry of Knowledge Economy, Korea

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The first complete synthesis of laetevirenol A was performed in nine steps via intramolecular Friedel-Crafts alkylation in a trans-selective manner. The key phenanthrene intermediate was synthesized by a one-pot Suzuki-Miyaura coupling and an aldol condensation cascade reaction.

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