4.7 Article

N-Heterocyclic Carbene Catalyzed Domino Cyclization of Propargylic Alcohols and Benzoyl Isocyanates

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 6, Pages 2924-2928

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo202102y

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Funding

  1. National Research Foundation
  2. Ministry of Education, Science and Technology [2010-0015432]

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N-Hetereocyclic carbenes (NHCs) were found to be efficient catalysts for the cyclization of propargylic alcohols and isocyanates. Domino cyclization reactions were carried out using isopropyl-substituted imidazolium salt as a precatalyst, and a wide range of substituted oxazolidinones were obtained in high yields.

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