Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 5, Pages 2360-2367Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo2026564
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- Deutsche Forschungsgemeinschaft
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The synthesis of 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, a natural product with antileishmanial activity recently isolated from the plant Galipea panamensis, is described. The key step is a Suzuki-Miyaura coupling of a furan-3-boronic acid and an 8-halocoumarin, which is advantageously synthesized using a ring-closing metathesis reaction. Several non-natural analogues are also available along these lines.
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