Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 14, Pages 6327-6331Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo300806y
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Funding
- Consolider-Ingenio [CSD2007-00006]
- Spanish Ministerio de Educacion
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Double addition (1,2-1,4) of vinyl magnesium bromide to squaric acid derivatives allows the preparation of polyoxygenated cyclopentenones (8) in a one-pot procedure. The reaction occurs through the intermediate formation of octatetraenes (6). Protonation of this latter intermediate at -78 degrees C with TFE occurs selectively at the vinyl CH2 closer to the metallic centers. DFT studies of the cyclization step justify the observed distereoselectivity.
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