Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 23, Pages 10699-10706Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo301980j
Keywords
-
Categories
Funding
- Graduate School of Molecular Science
- Deutsche Forschungsgemeinschaft (DFG)
Ask authors/readers for more resources
Substituted 2-aminobiphenyls have been prepared from arylhydrazines and anilines via radical arylation reactions under simple oxidative conditions. The strong directing effect of the free and unprotonated amino functionality leads to high regioselectivies, and anilines have been shown, to be significantly better aryl radical acceptors than nitrobenzenes or phenyl ethers. The methodology is also applicable to phenols, which react best as phenolates under strongly basic conditions. Finally, radical arylation reactions of anilines and anilinium salts under various conditions have for the first time demonstrated that regioselectivity can also be controlled through the rearomatization step and that the addition of an aryl radical to a substituted benzene might even be reversible.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available