4.7 Article

A Silver-Mediated One-Step Synthesis of Oxazoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 9, Pages 3519-3522

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo1025332

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Funding

  1. EPSRC
  2. AICR
  3. GSK
  4. University of Nottingham

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A silver-mediated one-step procedure to 2,,4-disubstituted and 2,4,5-trisubstituted oxazoles has been developed. The method is complementary to existing technologies, yet provides advantages with regard to simplicity, efficiency, and performance. The silver product can be readily recycled, thus minimizing waste.

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