4.7 Article

Synthesis of 2,4-Diiodoquinolines via the Photochemical Cyclization of o-Alkynylaryl Isocyanides with Iodine

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 4, Pages 1163-1166

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo1021772

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan [19350095]
  2. Society of Iodine Science
  3. Japan Society for the Promotion of Science (JSPS)
  4. Grants-in-Aid for Scientific Research [19350095] Funding Source: KAKEN

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Upon photoirradiation of o-alkynylaryl isocyanides in the presence of iodine, the intramolecular cyclization of o-alkynylaryl isocyanides proceeds to afford the corresponding 2,4-diiodoquinolines in good yields. 2,4-Diiodoquinolines can be employed in transition metal-catalyzed cross-coupling reactions.

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