Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 24, Pages 10005-10010Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo201756z
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Funding
- Seoul National University
- Singapore National Research Foundation [NRF-RF2008-05]
- Nanyang Technological University
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A well-defined N-heterocyclic carbene based ruthenium complex was developed as a highly active precatalyst for the direct amide synthesis from alcohols and secondary amines. Notably, reaction of 1-hexanol and dibenzylamine afforded 60% of the corresponding amide using our catalytic system, while no amide formation was observed for this reaction with the previously reported catalytic systems. Unlike the previously reported amidation with less sterically hindered alcohols and amines, involvement of ester intermediates was observed.
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