Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 2, Pages 396-402Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo101717m
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- DST, India
- CSIR, India
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From a systematic investigation involving the synthesis of a series of catalysts and screening studies, the organocatalyst 16, which is sterically hindered, contains a strong hydrogen-bonding site, and is endowed with reinforced chirality, is shown to promote the Biginelli cyclocondensation of aromatic as well as aliphatic aldehydes with ethyl acetoacetate and urea in a remarkably high enantioselectivity (ee ca. 94-99%).
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