Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 1, Pages 725-728Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo202078z
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Funding
- National Science Foundation [CHE-0955864, DGE-0707424]
- Boehringer Ingelheim
- DuPont
- Eli Lilly
- Amgen
- AstraZeneca
- University of California, Los Angeles
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0955864] Funding Source: National Science Foundation
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A concise synthesis of the Alzheimer's therapeutic (+)-phenserine is described. The approach features an interrupted Fischer indolization to construct the pyrrolidinoindoline core, in addition to a classical resolution to arrive at phenserine in enantioenriched form.
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