Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 18, Pages 7423-7430Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo201199k
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Funding
- NSFC [20872032, 20972044]
- NCET [08-0175]
- Chinese Ministry of Education [20100161110008]
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In this work, we have designed and synthesized the compound Ratio-HPSSC, based on a tetrakis(4-hydroxyphenyl)porphyrin coumarin scaffold, as a new ratiometric fluorescent probe for thiols. The ratiometric probe Ratio-HPSSC is highly selective and sensitive to thiols. Importantly, the novel ratiometric probe exhibited a remarkable change in emission color from red to blue. This key feature allows Ratio-HPSSC to be employed for thiol detection by simple visual inspection. Furthermore, we have demonstrated that Ratio-HPSSC is suitable for ratiometric fluorescence imaging of thiols in living cells. We believe that the new ratiometric probe will find interesting applications in chemistry, biology, and medicine.
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