Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 19, Pages 7938-7944Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo201402a
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Funding
- Indian Institute of Science
- CSIR
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A facile metal-free route of oxidative amination of benzoxazole by activation of C-H bonds with secondary or primary amines in the presence of catalytic iodine in aqueous tert-butyl hydroperoxide proceeds smoothly at ambient temperature under neat reaction condition to furnish the high yield of the aminated product. This user-friendly method to form C-N bonds produces tertiary butanol and water as the byproduct, which are environmentally benign. The application of the methodology is demonsrated by synthesizing therapeutically active benzoxazoles.
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