4.7 Article

Borrowing Hydrogen Methodology for Amine Synthesis under Solvent-Free Microwave Conditions

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 7, Pages 2328-2331

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo102521a

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Funding

  1. GlaxoSmithlaine
  2. Pfizer
  3. AstraZeneca
  4. Novartis
  5. EPSRC

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Application of microwave heating to the Borrowing Hydrogen strategy to form C-N bonds from alcohols and amines is presented, removing the need for solvent and reducing the reaction times while still yielding results comparable with those using thermal heating.

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