4.7 Article

Sodium Nitrite Catalyzed Aerobic Oxidative Deoximation under Mild Conditions

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 11, Pages 4665-4668

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo102571e

Keywords

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Funding

  1. National Natural Science Foundation of China [20702051]
  2. Educational Commission of Zhejiang Province [Y 200907685]

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A mild, simple process for the effective deoximation of a wide range of ketoximes and aldoximes has been developed, which utilizes available NaNO2 as the catalyst and molecular oxygen as the green oxidant. Notably Amberlyst-15, which acts as the initiator of NaNO2, can be reused without regeneration. This environmentally benign protocol could provide a valuable synthetic method for practical applications.

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