Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 9, Pages 3545-3550Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo200020z
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Funding
- Japan Society for the Promotion of Science [19550104, 14750665]
- Japan Science and Technology Agency (JST) [08-077]
- Central Glass Co., Ltd.
- Grants-in-Aid for Scientific Research [14750665, 19550104] Funding Source: KAKEN
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The organocatalytic asymmetric direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones in the presence of a catalytic amount of (S)-5-(pyrrolidin-2-yl)-1H-tetrazole in dichloroethane at 40 degrees C proceeds smoothly to produce (R)-4,4,4-trifluoro-1-aryl-3-hydroxy-1-butanones in high yields with up to 90% ee.
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