4.7 Article

One Approach to Cyclic Carbonates via a Three-Component Cyclization of Phenacyl Bromide, CO2, and Aldehyde

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 8, Pages 2459-2464

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo1020294

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Funding

  1. National Natural Science Foundation of China [NSFC 20973086]

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A three-component cyclization reaction was designed for synthesizing cyclic carbonates in a single operation from phenacyl bromide, CO2, and aldehyde in the presence of lithium diisopropylamide (LDA). These novel reactions were achieved under extremely mild conditions to generate the target products in moderate to good yields within 10 min.

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