4.7 Article

One-Pot Synthesis of 1,2-Dihydropyridines: Expanding the Diverse Reactivity of Propargyl Vinyl Ethers

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 7, Pages 2145-2156

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo102545m

Keywords

-

Funding

  1. Deutsche Forschungsgemeinschaft (DFG)
  2. Fonds der Chemischen Industrie (FCI)
  3. TUM Graduate School

Ask authors/readers for more resources

The catalyzed synthesis of 1,2-dihydropyridines starting from easily accessible propargyl vinyl ethers was realized. The reaction sequence involving a transition metal-catalyzed propargyl-Claisen re-arrangement; a condensation step, and a Bronsted acid-catalyzed heterocyclization furnishes the highly substituted heterocycles in moderate to excellent yields. Additionally, a practical one-pot protocol toward 1,2-dihydropyridines and 2H-pyrans starting from propargylic alcohols was developed.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available