Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 21, Pages 9144-9150Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo2015533
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Funding
- National Natural Science Foundation of China [20876147]
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Solvent-free reaction using a high-speed ball milling technique has been first applied to cross-dehydrogenative coupling (CDC) reactions between tetrahydroisoquinolines and three types of pronucleophiles such as nitroalkanes, alkynes, and indoles. All coupling products were obtained in good yields at short reaction times (no more than 40 min). When alkynes and indoles were used as pronucleophile, the reactions can be catalyzed efficiently by recoverable copper balls without any additional metal catalyst.
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