Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 24, Pages 10154-10162Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo201994v
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- CSIR, New Delhi, India
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An efficient synthesis toward highly diversified a-carboline derivatives via a three-component tandem reaction using acid chlorides, terminal allcynes, and 2-aminoindole hydrochlorides has been described. The salient feature of the one-pot strategy involves regioselective [3 + 3]-cyclocondensation and the presence of water in the reaction medium to facilitate cyclizafion. Nonaqueous conditions furnished products in poor yields.
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