4.7 Article

Direct C-N Coupling of Imidazoles and Benzylic Compounds via Iron-Catalyzed Oxidative Activation of C-H Bonds

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 18, Pages 7577-7582

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo201253m

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Funding

  1. Natural Science Foundation of China [20872129, 21072170]
  2. RFDP Foundation [20080-3350011]
  3. Fundamental Research Fund for the Central Universities [2010QNA3004]

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Iron-catalyzed direct C-N bond formation between imidazoles and benzylic hydrocarbons is described. The reaction utilizes an inexpensive iron catalyst-oxidant system that is suitable for the coupling of a range of benzylic C-H bonds with various imidazoles.

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