Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 13, Pages 4632-4635Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo1007338
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Funding
- National Institutes of Health [R01 GM087460-02]
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Sulfonation is prized for its ability to impart water-solubility to hydrophobic molecules such as dyes. This modification is usually performed as a final step, since sulfonated molecules are poorly soluble in most organic solvents, which complicates their synthesis and purification. This work compares the intrinsic lability of different sulfonate esters, identifying new sulfonate protecting groups and mild, selective cleavage conditions.
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