Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 23, Pages 8330-8332Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo1018798
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- Merck Future Talent Program
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A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd-2(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.
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